Technology InteGrator and AcceleratoR (TIGAR)

Amendment 3 (1) Appendix B was updated to remove track changes (2) Appendix C4 was updated to remove an erroneous comment. Amendment 2 (1) Instructions on how to submit a Solution Video were added to the ISO (see pages 7-8).

(2) Information related to the Video Captions file was added to Appendix B.0 (Solution Video Format and Instructions).

(3) The instructions in Appendix B.1 (Template for Supplemental Slides) were simplified, and a Cost Summary slide was added (see Slide 7).

(4) Appendix C.3 was updated to reference "Phase" rather than "Year" for clarity.

(5) The Administation and National Policy document in Appendix C.4 was replaced with an updated document. Amendment 1 The ISO was updated with the new webinar and webinar registration dates.

Effort Description: TIGAR Exploratory Topic will forge entirely new paths to stabilizing regenerative tissues and organs by seeding the development of enabling technologies that can unlock temperature-flexible storage in increasingly larger and more complex biological systems. Solutions may involve any combination of new materials, artificial intelligence/machine learning, high-throughput screening methods, biological interventions, devices, processing methods, analytical technology, and packaging approaches that can overcome current roadblocks and yield a leap in the ability to store and distribute complex biologics, without introducing high cost or complexity. Strategies that reduce reliance on strictly controlled temperature zones and can ensure safe storage in a range of environmental conditions are preferred. While long-term temperature-flexible storage is ideal, any advance that removes logistical hurdles or establishes shelf-life stability at easy to maintain temperatures (preferably non-cryogenic) will be considered. Innovations at the cellular level without a strategy for deployment in thick tissues will not be considered. Please ensure to follow this opportunity for any updates. For more information on the TIGAR Exploratory Topic visit: https://arpa-h.gov/explore-funding/initiatives-and-sprints/tigar For information on Proposer's Day details and registration information, please see Special Notice ARPA-H-SN-26-142